Most reports in the literature concern only the clinical and medical aspects of the condition. The herein findings emphasize the use of AS mouse model in characterizing and measuring inappropriate aggressive behavior, and suggests these as tools for investigating therapeutic interventions aimed at attenuating aggressive behavior. CHARGE syndrome has only been recognized for a little over 20 years. In contrast to the mild changes in affiliative behavior, there was a striking enhanced aggression in the AS mice compared to their WT littermates. However, overall there were no additional marked differences in affiliative social behavior. AS mice exhibited a unique characteristic of reduced habituation towards a social stimulus in comparison to their wild-type (WT) littermates. For that, we utilized a battery of behavioral paradigms, and performed detailed analyses of these behaviors. Hence, the aim of the herein study was to examine affiliative and aggressive social behavior. However, very few studies utilized this mouse model for investigating affiliative social behavior, and not even a single study examined aggressive behavior. A mouse model for AS recapitulates most of the human AS phenotypes. Atypical antipsychotics are associated with development of metabolic syndrome (weight gain, dyslipidemia, insulin resistance), risk of QTc prolongation, potential for development of extrapyramidal symptoms (akathisia, dystonia, secondary parkinsonism) and tardive dyskinesia, and the rare but serious risk of neuroleptic malignant syndrome (Solmi. The acronym is derived from the combination of the following problems: Coloboma of the eyes, Heart defects, Atresia of the choanae, Retardation of growth and/or development and/or central nervous system anomalies, Genital hypoplasia, Ear anomalies and/or deafness (Pagon et al. In addition, clinical surveys and case reports describe aggressive behavior in AS individuals as a severe difficulty for caretakers. CHARGE syndrome is a genetic disorder in which multiple anomalies are present from birth.

Inappropriate social interactions, usually hyper-sociability, is a part of that syndrome. As more patients an- di- agnosed and survive into their teens, specific medical, psycho- logical, behavioral, and educa- tional concerns arise that should be. Angelman syndrome (AS) is a genetic neurodevelopmental disorder due to the absence of the E3-ligase protein, UBE3A.

Charge syndrome and aggressive behavior